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serotonin antagonist and reuptake inhibitor : ウィキペディア英語版 | serotonin antagonist and reuptake inhibitor
Serotonin antagonist and reuptake inhibitors (SARIs) are a class of drugs used mainly as antidepressants, but also as anxiolytics and hypnotics. They act by antagonizing serotonin receptors such as 5-HT2A and inhibiting the reuptake of serotonin, norepinephrine, and/or dopamine. Additionally, most also act as α1-adrenergic receptor antagonists. The majority of the currently marketed SARIs belong to the phenylpiperazine class of compounds. ==List of SARIs==
* Etoperidone (Axiomin, Etonin) * Lorpiprazole (Normarex) * Lubazodone (YM-992, YM-35995) * Mepiprazole (Psigodal) * Nefazodone (Serzone, Nefadar) * Trazodone (Desyrel) Vilazodone is a related drug but does not fit into this class as it does not function as a serotonin antagonist, acting as a 5-HT1A receptor partial agonist instead. Niaprazine is also related to this group but does not inhibit the reuptake of serotonin or the other monoamines.
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